DNA methylation patterns associated with oxidative stress in an ageing population.

ABSTRACT:

Background

Oxidative stress has been related to type 2 diabetes (T2D) and cardiovascular disease (CVD), the leading global cause of death. Contributions of environmental factors such as oxidative stress on complex traits and disease may be partly mediated through changes in epigenetic marks (e.g. DNA methylation). Studies relating differential methylation with intermediate phenotypes and disease endpoints may be useful in identifying additional candidate genes and mechanisms involved in disease.

Methods

To investigate the role of epigenetic variation in oxidative stress marker levels and subsequent development of CVD and T2D, we performed analyses of genome-wide DNA methylation in blood, ten markers of oxidative stress (total glutathione [TGSH], reduced glutathione [GSH], ox

SUBMITTER: Hedman AK 

PROVIDER: S-EPMC5123374 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature