Emerging temporal trends in tissue plasminogen activator use: Results from the BASIC project.

ABSTRACT:

Objective

To explore temporal trends in tissue plasminogen activator (tPA) administration for acute ischemic stroke (AIS) in a biethnic community without an academic medical center and variation in trends by age, sex, ethnicity, and stroke severity.

Methods

Cases of AIS were identified from 7 hospitals in the Brain Attack Surveillance in Corpus Christi (BASIC) project, a population-based surveillance study between January 1, 2000, and June 30, 2012. tPA, demographics, and stroke severity as assessed by the NIH Stroke Scale (NIHSS) were ascertained from medical records. Temporal trends were explored using generalized estimating equations, and adjustment made for age, sex, ethnicity, and NIHSS. Interaction terms were included to test for effect modification.

Results

The

SUBMITTER: Domino JS 

PROVIDER: S-EPMC5123556 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature