BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity.

ABSTRACT: The AP-1 factor basic leucine zipper transcription factor, ATF-like (BATF) is important for CD4⁺ Th17, Th9, and follicular Th cell development. However, its precise role in Th2 differentiation and function remains unclear, and the requirement for BATF in nonallergic settings of type-2 immunity has not been explored. In this article, we show that, in response to parasitic helminths, Batf^-/- mice are unable to generate follicular Th and Th2 cells. As a consequence, they fail to establish productive type-2 immunity during primary and secondary infection. Batf^-/- CD4⁺ T cells do not achieve type-2 cytokine competency, which implies that BATF plays a key role in the regulation of IL-4 and IL-13. In contrast to Th17 and Th9 cell subsets in which BATF b

SUBMITTER: Bao K 

PROVIDER: S-EPMC5123670 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature