Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity.

ABSTRACT:

Background

Menopause is associated with significant hormonal changes that result in increased total body fat and abdominal fat, amplifying the risk for metabolic syndrome and diseases such as diabetes, cardiovascular disease and cancer in postmenopausal women. Intermittent fasting regimens hold significant health benefit promise for obese humans, however, regimens that include extreme daytime calorie restriction or daytime fasting are generally associated with hunger and irritability, hampering long-term compliance and adoption in the clinical setting. Time-restricted feeding (TRF), a regimen allowing eating only during a specific period in the normal circadian feeding cycle, without calorie restriction, may increase compliance and provide a more clinically viable method for reduci

SUBMITTER: Chung H 

PROVIDER: S-EPMC5123758 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature