Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling.

ABSTRACT: Immune tolerance between the fetus and mother represents an active process by which the developing fetus must not mount immune responses to noninherited Ags on chimeric maternal cells that reside in fetal tissue. This is, in part, mediated by the suppressive influence of CD4⁺FOXP3⁺CD25⁺ regulatory T cells (Tregs). Fetal secondary lymphoid organs have an increased frequency of Tregs and, as compared with adult T cells, fetal naive CD4⁺ T cells exhibit a strong predisposition to differentiate into Tregs when stimulated. This effect is mediated by the TCR and TGF-β pathways, and fetal T cells show significantly increased Treg differentiation in response to anti-CD3 and TGF-β stimulation. Naive fetal T cells also exhibit increased signaling through t

SUBMITTER: Bronevetsky Y 

PROVIDER: S-EPMC5123822 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature