Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders.

ABSTRACT:

Objectives

We demonstrated recently that the T1 relaxation rate (R1) captured short-term Mn exposure in welders with chronic, relatively low exposure levels in a cross-sectional study. In the current study, we used a longitudinal design to examine whether R1 values reflect the short-term dynamics of Mn exposure.

Methods

Twenty-nine welders were evaluated at baseline and 12 months. Occupational questionnaires estimated short-term welding exposure using welding hours in the 90days prior to each study visit (HrsW₉₀). In addition, blood Mn levels, the pallidal index (PI; globus pallidus T1-weighted intensity (T1WI)/frontal white matter T1WI), and R1 values in brain regions of interest (ROIs) were determined as Mn biomarkers at each visit. Associations between changes

SUBMITTER: Lewis MM 

PROVIDER: S-EPMC5123898 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature