Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.

ABSTRACT: The aim of the current work was to evaluate the ovarian follicle reserve and the ovarian transcriptome in Ames dwarf (df/df) mice. The results suggest a delayed ovarian aging in df/df mice compared to normal (N) mice. Although a high number of genes were differentially expressed during aging of N mice, only a small fraction of these changed with aging in df/df mice. These alterations involved more than 500 categorized biological processes. The majority of these biological processes, including inflammatory/immune responses, were up-regulated with aging in N mice, while old df/df mice were characterized by down-regulation of these same processes in comparison to age matched N mice. However, biological processes related to DNA damage and repairing were commonly down-regulated with aging in bo

SUBMITTER: Schneider A 

PROVIDER: S-EPMC5123904 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature