Low-Osmolar Diet and Adjusted Water Intake for Vasopressin Reduction in Autosomal Dominant Polycystic Kidney Disease: A Pilot Randomized Controlled Trial.

ABSTRACT:

Background

Autosomal dominant polycystic kidney disease (ADPKD) affects millions of people worldwide. Vasopressin promotes disease progression.

Study design

A randomized controlled trial with equal (1:1) allocation.

Setting & participants

This trial examined the effect of combining a low-osmolar (low-sodium [1,500mg/d], low-protein [0.8g per kilogram of body weight]) diet and adjusted water intake on vasopressin secretion in 34 patients with ADPKD.

Intervention

Participants were randomly assigned to receive a low-osmolar diet followed by adjusted water intake to achieve urine osmolality ≤ 280mOsm/kg water versus no intervention for 2 weeks.

Outcome

The primary outcome of the study was change (delta) in copeptin levels and urine osmolality between the int

SUBMITTER: Amro OW 

PROVIDER: S-EPMC5123924 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature