Ontology highlight
ABSTRACT:
SUBMITTER: Groner AC
PROVIDER: S-EPMC5124371 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20160526 6
Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-deprivation therapy is transiently effective in advanced disease, tumors often progress to a lethal castration-resistant state (CRPC). We show that recurrent PC-driver mutations in speckle-type POZ protein (SPOP) stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions. TRIM24 augments AR signaling, and AR and TRIM24 co-activated genes are significantly upregulated in CRPC. Ex ...[more]