AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis.

ABSTRACT: Multiple aspects of organismal physiology influence the number and activity of stem cells and their progeny, including nutritional status. Previous studies demonstrated that Drosophila germline stem cells (GSCs), follicle stem cells (FSCs), and their progeny sense and respond to diet via complex mechanisms involving many systemic and local signals. AMP-activated protein kinase, or AMPK, is a highly conserved regulator of energy homeostasis known to be activated under low cellular energy conditions; however, its role in the ovarian response to diet has not been investigated. Here, we describe nutrient-dependent and -independent requirements for AMPK in Drosophila oogenesis. We found that AMPK is cell autonomously required for the slow down in GSC and follicle cell proliferation that occurs

SUBMITTER: Laws KM 

PROVIDER: S-EPMC5124390 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature