Dopaminergic therapy removal differentially effects learning in schizophrenia and Parkinson's disease.

ABSTRACT: Studies of patients with Parkinson's disease receiving dopamimetics report conflicting evidence for early learning of probabilistic cue-outcome associations that elicits frontal-striatal activity. Previous studies of probabilistic association learning in patients with schizophrenia administered antipsychotics have displayed conflicting evidence for normal and abnormal learning. The role of dopaminergic treatment (dopamimetic versus dopamine antagonistic) effects on probabilistic association learning in these diseases that directly impact the dopamine system is not fully understood. The current study examined the effects of dopaminergic therapies on probabilistic association learning in 13 patients with schizophrenia and 8 patients with Parkinson's disease under two conditions: after withdr

SUBMITTER: Weickert TW 

PROVIDER: S-EPMC5124763 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature