Environmental factors linked to depression vulnerability are associated with altered cerebellar resting-state synchronization.

ABSTRACT: Hosting nearly eighty percent of all human neurons, the cerebellum is functionally connected to large regions of the brain. Accumulating data suggest that some cerebellar resting-state alterations may constitute a key candidate mechanism for depressive psychopathology. While there is some evidence linking cerebellar function and depression, two topics remain largely unexplored. First, the genetic or environmental roots of this putative association have not been elicited. Secondly, while different mathematical representations of resting-state fMRI patterns can embed diverse information of relevance for health and disease, many of them have not been studied in detail regarding the cerebellum and depression. Here, high-resolution fMRI scans were examined to estimate functional connectivity pa

SUBMITTER: Cordova-Palomera A 

PROVIDER: S-EPMC5124945 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature