IFIT1 polymorphisms predict interferon-α treatment efficiency for hepatitis B virus infection.

ABSTRACT:

Aim

To investigate the association between interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphisms and interferon-α (IFNα) treatment efficiency among Chinese hepatitis B virus (HBV) infection patients.

Methods

Two hundred and twenty five newly diagnosed chronic hepatitis B (CHB) patients were enrolled in the study. All of these patients received IFNα treatment for a course of 48 wk, and were followed up for 24 wk after the treatment was end. Clinical information about virological response, hepatitis B e antigen (HBeAg) seroconversion rate and combined response at the end of the treatment, as well as the sustained response by the time of following up 24 wk after the treatment, was collected. Four tag-single nucleotide polymorphisms (SNPs) of <

SUBMITTER: Xie DY 

PROVIDER: S-EPMC5124986 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature