Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice.

ABSTRACT: Inflammation, lipotoxicity and mitochondrial dysfunction have been implicated in the pathogenesis of obesity-induced insulin resistance and type 2 diabetes. However, how these factors are intertwined in the development of obesity/insulin resistance remains unclear. Here, we examine the role of mitochondrial fat oxidation on lipid-induced inflammation in skeletal muscle. We used skeletal muscle-specific Cpt1b knockout mouse model where the inhibition of mitochondrial fatty acid oxidation results in accumulation of lipid metabolites in muscle and elevated circulating free fatty acids. Gene expression of pro-inflammatory cytokines, chemokines, and cytokine- and members of TLR-signalling pathways were decreased in Cpt1b^m-/- muscle. Inflammatory signalling pathways were not activated

SUBMITTER: Warfel JD 

PROVIDER: S-EPMC5124994 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature