EWAS: epigenome-wide association studies software 1.0 - identifying the association between combinations of methylation levels and diseases.

ABSTRACT: Similar to the SNP (single nucleotide polymorphism) data, there is non-random association of the DNA methylation level (we call it methylation disequilibrium, MD) between neighboring methylation loci. For the case-control study of complex diseases, it is important to identify the association between methylation levels combination types (we call it methylecomtype) and diseases/phenotypes. We extended the classical framework of SNP haplotype-based association study in population genetics to DNA methylation level data, and developed a software EWAS to identify the disease-related methylecomtypes. EWAS can provide the following basic functions: (1) calculating the DNA methylation disequilibrium coefficient between two CpG loci; (2) identifying the MD blocks across the whole genome; (3) carryin

SUBMITTER: Xu J 

PROVIDER: S-EPMC5125000 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature