Hyperlipidemia Promotes Anti-Donor Th17 Responses That Accelerate Allograft Rejection.

ABSTRACT: Hyperlipidemia occurs in 95% of organ transplant recipients, however its effect on organ allograft rejection has not been investigated. We found that induction of hyperlipidemia in mice caused a significant acceleration of rejection of cardiac allografts. Accelerated rejection was associated with an aggressive T cell infiltrate that mediated significant tissue damage as well as increased serum levels of the proinflammatory cytokines IL-2, IL-6, and IL-17. Hyperlipidemic mice had an increased number of Th17 cells in their periphery and rejecting allografts from hyperlipidemic mice contained significant numbers of IL-17 producing T cells that were not detectable in transplants harvested from controls. Neutralization or genetic ablation of IL-17 prolonged survival of cardiac allografts transp

SUBMITTER: Yuan J 

PROVIDER: S-EPMC5125017 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature