Blastomere biopsy for PGD delays embryo compaction and blastulation: a time-lapse microscopic analysis.

ABSTRACT:

Purpose

The purpose of the study was to explore the effect of blastomere biopsy for preimplantation genetic diagnosis (PGD) on the embryos' dynamics, further cleavage, development, and implantation.

Methods

The study group included 366 embryos from all PGD treatments (September 2012 to June 2014) cultured in the EmbryoScope™ time-lapse monitoring system. The control group included all intracytoplasmic sperm injection (ICSI) embryos cultured in EmbryoScope™ until day 5 during the same time period (385 embryos). Time points of key embryonic events were analyzed with an EmbryoViewer™.

Results

Most (88 %) of the embryos were biopsied at ≥8 cells. These results summarize the further dynamic development of the largest cohort of biopsied embryos and demonstrate that blastome

SUBMITTER: Bar-El L 

PROVIDER: S-EPMC5125156 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature