Reduced Hemispheric Asymmetry of White Matter Microstructure in Autism Spectrum Disorder.

ABSTRACT:

Objective

Many past studies have suggested atypical functional and anatomical hemispheric asymmetries in autism spectrum disorder (ASD). However, almost all of these have examined only language-related asymmetries. Here, we conduct a comprehensive investigation of microstructural asymmetries across a large number of fiber tracts in ASD.

Method

We used diffusion tensor imaging for a comprehensive investigation of anatomical white matter asymmetries across the entire white matter skeleton, using tract-based spatial statistics in 41 children and adolescents with ASD and a matched group of 44 typically developing (TD) participants.

Results

We found significant asymmetries in the TD group, being rightward for fractional anisotropy and leftward for mean diffusivity (with co

SUBMITTER: Carper RA 

PROVIDER: S-EPMC5125511 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature