Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy.

ABSTRACT: Preterm labor and infections are the leading causes of neonatal deaths worldwide. During pregnancy, immunological cross talk between the mother and her fetus is critical for the maintenance of pregnancy and the delivery of an immunocompetent neonate. A precise understanding of healthy fetomaternal immunity is the important first step to identifying dysregulated immune mechanisms driving adverse maternal or neonatal outcomes. This study combined single-cell mass cytometry of paired peripheral and umbilical cord blood samples from mothers and their neonates with a graphical approach developed for the visualization of high-dimensional data to provide a high-resolution reference map of the cellular composition and functional organization of the healthy fetal and maternal immune systems at birt

SUBMITTER: Fragiadakis GK 

PROVIDER: S-EPMC5125527 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature