The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse.

ABSTRACT:

Objective

To determine the role of the aryl hydrocarbon receptor (AHR) in colitis-associated colorectal tumorigenesis.

Background

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in United States. Chronic intestinal inflammation increases the risk for the development of CRC. We investigated the involvement of AHR, a ligand-activated transcriptional regulator, in colitis-associated colorectal tumorigenesis.

Methods

We used a mouse model of colitis-associated colorectal tumorigenesis that employs treatment with azoxymethane and dextran sodium sulfate. We examined the role of AHR using both an Ahr-deletion mouse model (Ahr) and treatment with the AHR pro-agonist indole-3-carbinol (I3C). Incidence, multiplicity, and location of tumors were visually coun

SUBMITTER: Diaz-Diaz CJ 

PROVIDER: S-EPMC5125557 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature