Diet-Induced Nutritional Stress and Pathogen Interference in Wolbachia-Infected Aedes aegypti.

ABSTRACT: The pathogen interference phenotype greatly restricts infection with dengue virus (DENV) and other pathogens in Wolbachia-infected Aedes aegypti, and is a vital component of Wolbachia-based mosquito control. Critically, the phenotype's causal mechanism is complex and poorly understood, with recent evidence suggesting that the cause may be species specific. To better understand this important phenotype, we investigated the role of diet-induced nutritional stress on interference against DENV and the avian malarial parasite Plasmodium gallinaceum in Wolbachia-infected Ae. aegypti, and on physiological processes linked to the phenotype. Wolbachia-infected mosquitoes were fed one of four different concentrations of sucrose, and then challenged with either P. gallinaceum or DENV. Interference ag

SUBMITTER: Caragata EP 

PROVIDER: S-EPMC5125575 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature