An adenovirus-derived protein: A novel candidate for anti-diabetic drug development.

ABSTRACT:

Aims

Exposure to human adenovirus Ad36 is causatively and correlatively linked with better glycemic control in animals and humans, respectively. Although the anti-hyperglycemic property of Ad36 may offer some therapeutic potential, it is impractical to use an infectious agent for therapeutic benefit. Cell-based studies identified that Ad36 enhances cellular glucose disposal via its E4orf1 protein. Ability to improve glycemic control in vivo is a critical prerequisite for further investigating the therapeutic potential of E4orf1. Therefore, the aim of this study was to determine the ability of E4orf1 to improve glycemic control independent of insulin despite high fat diet.

Materials & methods

8-9wk old male C57BL/6J mice fed a high-fat diet (60% kcal) were injected with a ret

SUBMITTER: Hegde V 

PROVIDER: S-EPMC5125614 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature