Circadian Variation of Plasminogen-Activator-Inhibitor-1 Levels in Children with Meningococcal Sepsis.

ABSTRACT:

Objective

To study whether the circadian variation of plasminogen-activator-inhibitor-1 (PAI-1) levels, with high morning levels, is associated with poor outcome of children with meningococcal sepsis presenting in the morning hours.

Design

Retrospective analysis of prospectively collected clinical and laboratory data.

Setting

Single center study at Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

Subjects

184 patients aged 3 weeks to 18 years with meningococcal sepsis. In 36 of these children, PAI-1 levels at admission to the PICU were measured in plasma by ELISA.

Interventions

None.

Measurements and main results

Circadian variation was studied by dividing one day in blocks of 6 hours. Patients admitted between 6:00 am and 12:00

SUBMITTER: Boeddha NP 

PROVIDER: S-EPMC5125643 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature