Genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease.

ABSTRACT:

Introduction

Genetic factors and environmental exposures, including pesticides, contribute to the risk of Parkinson's disease (PD). There have been few studies of gene and pesticide exposure interactions in PD, and all of the prior studies used a candidate gene approach.

Methods

We performed the first genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease. Analyses were performed using data on >700,000 single nucleotide polymorphisms (SNPs) in 364 discordant sibling pairs. In addition to testing for SNP-pesticide interaction effects, we also performed exploratory analyses of gene-pesticide interactions at the gene level.

Results

None of the gene-environment interaction results were significant after genome-wide correcti

SUBMITTER: Biernacka JM 

PROVIDER: S-EPMC5125780 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature