Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos.

ABSTRACT: Fidelity of histone gene expression is important for normal cell growth and differentiation that is stringently controlled during development but is compromised during tumorigenesis. Efficient production of histones for packaging newly replicated DNA is particularly important for proper cell division and epigenetic control during the initial pre-implantation stages of embryonic development. Here, we addressed the unresolved question of when the machinery for histone gene transcription is activated in the developing zygote to accommodate temporal demands for histone gene expression. We examined induction of Histone Nuclear Factor P (HINFP), the only known transcription factor required for histone H4 gene expression, that binds directly to a unique H4 promoter-specific element to regulate hi

SUBMITTER: Ghule PN 

PROVIDER: S-EPMC5125829 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature