Human adult neurogenesis across the ages: An immunohistochemical study.

ABSTRACT:

Aims

Neurogenesis in the postnatal human brain occurs in two neurogenic niches; the subventricular zone (SVZ) in the wall of the lateral ventricles and the subgranular zone (SGZ) of the hippocampus. The extent to which this physiological process continues into adulthood is an area of ongoing research. This study aimed to characterize markers of cell proliferation and assess the efficacy of antibodies used to identify neurogenesis in both neurogenic niches of the human brain.

Methods

Cell proliferation and neurogenesis were simultaneously examined in the SVZ and SGZ of 23 individuals aged 0.2-59 years, using immunohistochemistry and immunofluorescence in combination with unbiased stereology.

Results

There was a marked decline in proliferating cells in both neurogenic n

SUBMITTER: Dennis CV 

PROVIDER: S-EPMC5125837 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature