Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye.

ABSTRACT: Yap functions as a transcriptional regulator by acting together with sequence-specific DNA binding factors and transcription cofactors to mediate cell proliferation in developing epithelial tissues and tumors. An upstream kinase cascade controls nuclear localization and function in response to partially identified exogenous signals, including cell-to-cell contact. Nevertheless, its role in CNS development is poorly understood. In order to investigate Yap function in developing CNS, we characterized the cellular outcomes after selective Yap gene ablation in developing ocular tissues. When Yap was lost, presumptive retinal pigment epithelium acquired anatomical and molecular characteristics resembling those of the retinal epithelium rather than of RPE, including loss of pigmentation, pseudos

SUBMITTER: Kim JY 

PROVIDER: S-EPMC5125893 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature