Estimation of the HIV-1 backward mutation rate from transmitted drug-resistant strains.

ABSTRACT: One of the serious threats facing the administration of antiretroviral therapy to human immunodeficiency virus (HIV-1) infected patients is the reported increasing prevalence of transmitted drug resistance. However, given that HIV-1 drug-resistant strains are often less fit than the wild-type strains, it is expected that drug-resistant strains that are present during the primary phase of the HIV-1 infection are replaced by the fitter wild-type strains. This replacement of HIV-1 resistant mutations involves the emergence of wild-type strains by a process of backward mutation. How quickly the replacement happens is dependent on the class of HIV-1 mutation group. We estimate the backward mutation rates and relative fitness of various mutational groups known to confer HIV-1 drug resistance. We

SUBMITTER: Kitayimbwa JM 

PROVIDER: S-EPMC5126109 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature