Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India.

ABSTRACT: Epidemiological studies suggest that India has the largest number of dengue virus infection cases worldwide. However, there is minimal information about the immunological responses in these patients. CD8 T cells are important in dengue, because they have been implicated in both protection and immunopathology. Here, we provide a detailed analysis of HLA-DR⁺ CD38⁺ and HLA-DR^- CD38⁺ effector CD8 T cell subsets in dengue patients from India and Thailand. Both CD8 T cell subsets expanded and expressed markers indicative of antigen-driven proliferation, tissue homing, and cytotoxic effector functions, with the HLA-DR⁺ CD38⁺ subset being the most striking in these effector qualities. The breadth of the dengue-specific CD8 T cell re

SUBMITTER: Chandele A 

PROVIDER: S-EPMC5126381 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature