Lack of Fibronectin Extra Domain A Alternative Splicing Exacerbates Endothelial Dysfunction in Diabetes.

ABSTRACT: Glucose-induced changes of artery anatomy and function account for diabetic vascular complications, which heavily impact disease morbidity and mortality. Since fibronectin containing extra domain A (EDA + FN) is increased in diabetic vessels and participates to vascular remodeling, we wanted to elucidate whether and how EDA + FN is implicated in diabetes-induced endothelial dysfunction using isometric-tension recording in a murine model of diabetes. In thoracic aortas of EDA^-/-, EDA^+/+ (constitutively lacking and expressing EDA + FN respectively), and of wild-type mice (EDA^wt/wt), streptozotocin (STZ)-induced diabetes impaired endothelial vasodilation to acetylcholine, irrespective of genotype. However STZ + EDA^-/- mice exhibited increased endoth

SUBMITTER: Gortan Cappellari G 

PROVIDER: S-EPMC5126581 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature