PET/MRI of Hypoxic Atherosclerosis Using 64Cu-ATSM in a Rabbit Model.

ABSTRACT: The macrophage-rich core of advanced human atheroma has been demonstrated to be hypoxic, which may have implications in plaque stability. The goal of this study was to determine the feasibility of the hypoxia PET imaging agent ⁶⁴Cu-ATSM to detect hypoxia in a rabbit model of atherosclerosis imaged on a simultaneous PET/MR scanner, using MR for both attenuation correction and depiction of lesion location.

Methods

New Zealand White rabbits fed a Western diet for 4-6 wk underwent endothelial denudation of the right femoral artery by air desiccation to induce an atherosclerotic-like lesion and underwent a sham operation on the left femoral artery. Four and 8 wk after injury, a 0- to 60-min dynamic whole-body PET/MR examination was performed after injection of approximately 11

SUBMITTER: Nie X 

PROVIDER: S-EPMC5126698 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature