Evidence of functional divergence in MSP7 paralogous proteins: a molecular-evolutionary and phylogenetic analysis.

ABSTRACT:

Background

The merozoite surface protein 7 (MSP7) is a Plasmodium protein which is involved in parasite invasion; the gene encoding it belongs to a multigene family. It has been proposed that MSP7 paralogues seem to be functionally redundant; however, recent experiments have suggested that they could have different roles.

Results

The msp7 multigene family has been described in newly available Plasmodium genomes; phylogenetic relationships were established in 12 species by using different molecular evolutionary approaches for assessing functional divergence amongst MSP7 members. Gene expansion and contraction rule msp7 family evolution; however, some members could have had concerted evolution. Molecular evolutionary analysis showed that relaxed and/or intensified selection mo

SUBMITTER: Garzon-Ospina D 

PROVIDER: S-EPMC5126858 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature