Association Between Blood Pressure and Adverse Renal Events in Type 1 Diabetes.

ABSTRACT:

Objective

To compare different blood pressure (BP) levels in their association with the risk of renal outcomes in type 1 diabetes and to determine whether an intensive glycemic control strategy modifies this association.

Research design and methods

We included 1,441 participants with type 1 diabetes between the ages of 13 and 39 years who had previously been randomized to receive intensive versus conventional glycemic control in the Diabetes Control and Complications Trial (DCCT). The exposures of interest were time-updated systolic BP (SBP) and diastolic BP (DBP) categories. Outcomes included macroalbuminuria (>300 mg/24 h) or stage III chronic kidney disease (CKD) (sustained estimated glomerular filtration rate <60 mL/min/1.73 m²).

Results

During a median

SUBMITTER: Ku E 

PROVIDER: S-EPMC5127223 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature