APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND.

ABSTRACT:

Objective

Dementia is a debilitating illness with a disproportionate burden in patients with type 2 diabetes (T2D). Among the contributors, genetic variation at the apolipoprotein E locus (APOE) is posited to convey a strong effect. This study compared and contrasted the association of APOE with cognitive performance and cerebral structure in the setting of T2D.

Research design and methods

European Americans from the Diabetes Heart Study (DHS) MIND (n = 754) and African Americans from the African American (AA)-DHS MIND (n = 517) were examined. The cognitive battery assessed executive function, memory, and global cognition, and brain MRI was performed.

Results

In European Americans and African Americans, the APOE E4 risk haplotype group was associated with poorer perfo

SUBMITTER: Palmer Allred ND 

PROVIDER: S-EPMC5127235 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature