Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5127278 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cancer cell 20161103 5
Mutations in SF3B1, which encodes a spliceosome component, are associated with poor outcome in chronic lymphocytic leukemia (CLL), but how these contribute to CLL progression remains poorly understood. We undertook a transcriptomic characterization of primary human CLL cells to identify transcripts and pathways affected by SF3B1 mutation. Splicing alterations, identified in the analysis of bulk cells, were confirmed in single SF3B1-mutated CLL cells and also found in cell lines ectopically expre ...[more]