Body mass index and risk of non-melanoma skin cancer: cumulative evidence from prospective studies.

ABSTRACT: Prospective epidemiologic studies that investigated the association between body mass index (BMI) and non-melanoma skin cancer (NMSC) yielded inconsistent findings. A dose-response meta-analysis was conducted to quantitatively summarize the evidence. PubMed and Embase databases were searched for relevant studies. Study-specific relative risk (RR) and 95% confidence interval (CI) for an increase in BMI of 5 kg/m² was computed with the generalized least squares trend estimation, and these risk estimates were combined with the random-effects model. Nine publications were included in the final analyses, consisting of 18 independent cohorts with 22 risk estimates (971,795 participants and 50,561 NMSC cases). Results of the dose-response analyses showed a nonlinear inverse relationshi

SUBMITTER: Zhou D 

PROVIDER: S-EPMC5127294 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature