Ontology highlight
ABSTRACT:
SUBMITTER: Feric M
PROVIDER: S-EPMC5127388 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Cell 20160519 7
The nucleolus and other ribonucleoprotein (RNP) bodies are membrane-less organelles that appear to assemble through phase separation of their molecular components. However, many such RNP bodies contain internal subcompartments, and the mechanism of their formation remains unclear. Here, we combine in vivo and in vitro studies, together with computational modeling, to show that subcompartments within the nucleolus represent distinct, coexisting liquid phases. Consistent with their in vivo immisci ...[more]