Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs.

ABSTRACT:

Introduction

The number of cases of drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has risen rapidly in recent years. This has led to the resurgence in repurposing existing drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), for anti-TB treatment.

Sources of data

Evidence from novel drug screening in vitro, in vivo, pharmacokinetic/pharmacodynamics analyses and clinical trials has been used for the preparation of this systematic review of the potential of NSAIDs for use as an adjunct in new TB chemotherapies.

Areas of agreement

Certain NSAIDs have demonstrated inhibitory properties towards actively replicating, dormant and drug-resistant clinical isolates of M. tuberculosis cells.

Areas of controversy

NSAIDs are

SUBMITTER: Maitra A 

PROVIDER: S-EPMC5127427 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature