Racial Differences in Gray Matter Integrity by Diffusion Tensor in Black and White Octogenarians.

ABSTRACT:

Objective

To quantify racial differences in brain structural characteristics in white and black octogenarians, and to examine whether these characteristics contribute to cognition.

Methods

Cross-sectional study of 283 adults 79-89 years old (59.4% white;42.0% women) with data on gray matter integrity via diffusion tensor imaging (mean diffusivity), gray matter atrophy (GMA), white matter hyperintensities (WMH), literacy, smoking, drinking, income, hypertension and diabetes. Participants were recruited from an ongoing epidemiological study of older adults living in the community with a range of chronic conditions, physical and cognitive function. Standardized betas (sβ) of neuroimaging markers predicting Digit Symbol Substitution Test (DSST) and Modified Mini-Mental State Exa

SUBMITTER: Liu G 

PROVIDER: S-EPMC5127649 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature