Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors.

ABSTRACT:

Purpose

Pancreatic ductal adenocarcinoma (PDAC) is lethal cancer whose primary tumor is characterized by dense composition of cancer cells, stromal cells, and extracellular matrix (ECM) composed largely of collagen. Within the PDAC tumor microenvironment, activated pancreatic stellate cells (PSC) are the dominant stromal cell type and responsible for collagen deposition. Lumican is a secreted proteoglycan that regulates collagen fibril assembly. We have previously identified that the presence of lumican in the ECM surrounding PDAC cells is associated with improved patient outcome after multimodal therapy and surgical removal of localized PDAC.

Experimental design

Lumican expression in PDAC from 27 patients was determined by IHC and quantitatively analyzed for colocalization

SUBMITTER: Kang Y 

PROVIDER: S-EPMC5127652 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature