Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

ABSTRACT: Cellular identity in metazoan organisms is frequently established through lineage-specifying transcription factors, which control their own expression through transcriptional positive feedback, while antagonizing the developmental networks of competing lineages. Here, we have uncovered a distinct positive feedback loop that arises from the reciprocal stabilization of the tyrosine kinase ABL and the transcriptional coactivator TAZ. Moreover, we determined that this loop is required for osteoblast differentiation and embryonic skeletal formation. ABL potentiated the assembly and activation of the RUNX2-TAZ master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARγ-mediated adipogenesis. ABL also enhanced TAZ nuclear localization and the formation of

SUBMITTER: Matsumoto Y 

PROVIDER: S-EPMC5127668 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature