Ontology highlight
ABSTRACT:
SUBMITTER: Dallavalle C
PROVIDER: S-EPMC5127674 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20161107 12
Mutations and deletions in components of ubiquitin ligase complexes that lead to alterations in protein turnover are important mechanisms in driving tumorigenesis. Here we describe an alternative mechanism involving upregulation of the microRNA miR-424 that leads to impaired ubiquitination and degradation of oncogenic transcription factors in prostate cancers. We found that miR-424 targets the E3 ubiquitin ligase COP1 and identified STAT3 as a key substrate of COP1 in promoting tumorigenic and c ...[more]