Effect of Heart Failure With Preserved Ejection Fraction on Nitric Oxide Metabolites.

ABSTRACT: Endothelial function may be deranged in heart failure with preserved ejection fraction (HFpEF). Serum NO-derived metabolites (NO_m) might provide a biochemical surrogate of endothelial function in patients with heart failure (HF). We measured serum NO_m in 415 participants in the Penn HF Study. Participants with HFpEF (n = 82) and those whose EF had recovered (Recovered-HF, n = 125) were matched 1:1 to heart failure with reduced ejection fraction (HFrEF) participants based on age, gender, race, tobacco use, and eGFR. Serum NO_m levels were quantified after chemical reduction coupled with gas-phase chemiluminescence detection. After adjustment for matching covariates and BMI, HFpEF (34.5 μM; interquartile range [IQR] 25.0, 51.5) participants had lower NO_m<

SUBMITTER: Zamani P 

PROVIDER: S-EPMC5127733 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature