Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.

ABSTRACT: Disruptive, damaging ultra-rare variants in highly constrained genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE). This effect was stronger among highly brain-expressed genes and explained more YOE variance than pathogenic copy number variation but less than common variants. Disruptive, damaging ultra-rare variants in highly constrained genes influence the determinants of YOE in the general population.

SUBMITTER: Ganna A 

PROVIDER: S-EPMC5127781 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature