Datasets for the validation of the "in vivo" siRNA-silencing of CD40 and for the detection of new markers of atherosclerosis progression in ApoE-deficient mice.

ABSTRACT: Data presented in this Data in Brief article correspond to the article "in vivo" silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis" (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE^-/- mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80⁺, galectin-3⁺ macrophages or by NF-κB⁺ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediator

SUBMITTER: Hueso M 

PROVIDER: S-EPMC5128022 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature