Linkage and Association Analyses of Schizophrenia with Genetic Variations on Chromosome 22q11 in Koreans.

ABSTRACT:

Objective

Chromosome 22q11 has been implicated as a susceptibility locus of schizophrenia. It also contains various candidate genes for which evidence of association with schizophrenia has been reported. To determine whether genetic variations in chromosome 22q11 are associated with schizophrenia in Koreans, we performed a linkage analysis and case-control association study.

Methods

Three microsatellite markers within a region of 4.35 Mb on 22q11 were genotyped for 47 multiplex schizophrenia families, and a non-parametric linkage analysis was applied. The association analysis was done with 227 unrelated patients and 292 normal controls. For 39 single nucleotide polymorphisms (SNPs) spanning a 1.4 Mb region (33 kb interval) containing four candidate schizophrenia genes (DG

SUBMITTER: Yoon SC 

PROVIDER: S-EPMC5128351 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature