Digital gene expression profiling analysis of duodenum transcriptomes in SD rats administered ferrous sulfate or ferrous glycine chelate by gavage.

ABSTRACT: The absorption of different iron sources is a trending research topic. Many studies have revealed that organic iron exhibits better bioavailability than inorganic iron, but the concrete underlying mechanism is still unclear. In the present study, we examined the differences in bioavailability of ferrous sulfate and ferrous glycinate in the intestines of SD rats using Illumina sequencing technology. Digital gene expression analysis resulted in the generation of almost 128 million clean reads, with expression data for 17,089 unigenes. A total of 123 differentially expressed genes with a |log2(fold change)| >1 and q-value < 0.05 were identified between the FeSO₄ and Fe-Gly groups. Gene Ontology functional analysis revealed that these genes were involved in oxidoreductase activity,

SUBMITTER: Zhuo Z 

PROVIDER: S-EPMC5128800 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature