Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation.

ABSTRACT: Resveratrol is a natural compound found in red wine that has been suggested to exert its potential health benefit through the activation of SIRT1, a crucial member of the mammalian NAD⁺-dependent deacetylases. SIRT1 has emerged as an attractive therapeutic target for many aging related diseases, however, how its activity can only be activated toward some specific substrates by resveratrol has been poorly understood. Herein, by employing extensive molecular dynamics simulations as well as fragment-centric topographical mapping of binding interfaces, we have clarified current controversies in the literature and elucidated that resveratrol plays an important activation role by stabilizing SIRT1/peptide interactions in a substrate-specific manner. This new mechanism highlights the i

SUBMITTER: Hou X 

PROVIDER: S-EPMC5128864 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature