Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/Mena^INV-initiated invadopodium formation.

ABSTRACT: The process of intravasation involving transendothelial migration is a key step in metastatic spread. How the triple cell complex composed of a macrophage, Mena over-expressing tumor cell and endothelial cell, called the tumor microenvironment of metastasis (TMEM), facilitates tumor cell transendothelial migration is not completely understood. Previous work has shown that the physical contact between a macrophage and tumor cell results in the formation of invadopodia, actin-rich matrix degrading protrusions, important for tumor cell invasion and transendothelial migration and tumor cell dissemination. Herein, we show that the macrophage-induced invadopodium is formed through a Notch1/Mena^INV signaling pathway in the tumor cell upon macrophage contact. This heterotypic tumor cell

SUBMITTER: Pignatelli J 

PROVIDER: S-EPMC5129016 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature