Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects.

ABSTRACT:

Background

Visceral fat plays a central role in the development of metabolic syndrome and atherosclerotic cardiovascular diseases. The association of visceral fat accumulation with cardio-metabolic diseases has been reported, but the impact of visceral fat on the gene expression profile in peripheral blood cells remains to be determined. The aim of this study was to determine the effects of visceral fat area (VFA) and subcutaneous fat area (SFA) on the gene expression profile in peripheral blood cells of obese subjects.

Methods

All 17 enrolled subjects were hospitalized to receive diet therapy for obesity (defined as body mass index, BMI, greater than 25 kg/m²). VFA and SFA were measured at the umbilical level by computed tomography (CT). Blood samples were subjec

SUBMITTER: Obata Y 

PROVIDER: S-EPMC5129204 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature